I want to compute chi-square and p-value for a 2x2 matrix. What Python library should I use to calculate these values?

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You can perform either a Fisher exact test or Chi-square test to calculate p-value. For chi-square, you need to perform Chi-square test. Scipy library has functions for both of these tests.**Fisher exact test on a 2x2 contingency table**

>>> obs

array([[60, 14],

[19, 80]])

>>> from scipy.stats import fisher_exact

>>> oddsratio, pvalue = fisher_exact(obs)

>>> pvalue

1.4292844716515043e-16

>>> oddsratio

18.045112781954888

**Chi-square test of independence of variables in a contingency table. **

>>> obs

array([[60, 14],

[19, 80]])

>>> chi, pvalue, dof, ex = chi2_contingency(obs)

>>> chi

62.900798319007976

>>> pvalue

2.1738410013620548e-15

>>> dof

1L

>>>